Archive for ADULT

PLEASE GO TO MY NEW STEM CELL BLOG BY CLICKING ON “PRESS ME”

Posted in ALL ARTICLES with tags , , , , , , , , , , , on April 7, 2009 by David Granovsky

14 MONTHS,

940 POSTS and

890,000 VISITS.

..STEM CELL BLOG

STEM CELL BLOG

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Saving Stem Cells – Banking Stem Cells – From your teeth

Posted in ALL ARTICLES, STEM CELLS IN THE NEWS with tags , , , , , , , , , , on April 7, 2009 by David Granovsky

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Saving Stem Cells – Banking Stem Cells – From your teeth

Kristin Lowman

Megan Brown is no stranger to surgery. At 10 years old, Megan had a brain tumor

Megan says, “two surgeries to get the turmor out, now, I’m fine.”

So today’s wisdom teeth removal is nearly a walk in the park for Megan and her family.

But this procedure is special, because one day, it could save her life.

Megan says, “its been a recent discovery that your wisdom teeth contain stem cells. So I’m going to bank them.”

Dr. Robert Carpenter says, “in teeth, particularly dediuous baby teeth and wisdom teeth there is a tremendous quality of stem cells.”

There are two sources of stem cells, embryonic and adult. Obtaining embryonic stem cells is quite controversial while adult stem cells can be found in many organs and tissues in the body, including your teeth.

Living stem cells in extracted teeth are usually thrown out, but now, research shows saving those cells, could help with medical treatments down the road.

Dr. Carpenter uses a service called Stem Save, to harvest the stem cells.

Stem Save also tests the viability of those cells and cryogenically freezes them until they are needed.

Dr. Carpenter says, “you’re getting your own stem cells so there is no chance for rejection, no disease, and you can personalize them for any use you need throughout your life.”

Right now, dental stem cells are being used to treat MS, Parkinson’s, even liver and heart disease. Several hundred clinical trials are also underway around the world.

In just over a year, around 200 dentists across the country are using this service alone.

For Megan and her parents, its a safety net they are glad to have.

They start up cost for the service is around $600. Thats for testing the cells and for the first year of storage.

Right now, Dr. Carpenter says the service is not covered by insurance

via Saving Stem Cells – FOX23 News – The 10 O’Clock News.

www.Stemsave.com

Adult Stem Cells Are What Work

Posted in ALL ARTICLES, STEM CELLS IN THE NEWS with tags , , , , , , , , , on April 7, 2009 by David Granovsky

I think this Rep has been reading my blog and drinking the kool-aid! Only a few corrections to what he wrote. -dg

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Adult Stem Cells Are What Work

by Rep. J. Randy Forbes, 04/07/2009

Prof. Ian Wilmut of Edinburgh University is hardly a household name. However, most people would recognize his Nobel-Prize-winning scientific development. Prof. Wilmut was the individual who led the team that created the cloned sheep Dolly and pioneered a technique many would want to use for a type of embryonic stem-cell research. His action resulted in both uproar and applause all over the world and was instrumental in bringing the discussion of cloning and stem-cell research from the laboratory to the dinner table.

For years, the moral and ethical issue of destroying human embryos for scientific experimentation has been the biggest argument against embryonic stem-cell research.

(besides causing tumors and severe rejection issues -dg)

But now there is a new argument against embryonic stem-cell research: science.

Just recently, President Obama signed an executive order lifting the ban on the use of federal funds for embryonic stem-cell research, an act based more on politics than it was on science. (Private funding for this research has never been banned.) His action reignited the contentious issue for many individuals in the U.S. — it also ignored the miracles we’ve seen in advancing science.

Adult stem-cells are derived from umbilical cords, wisdom teeth, amniotic fluid, and various tissues, and they don’t hold the same ethical concerns that stem-cells taken from human embryos do. Over the years, adult stem cells have resulted in 73 successful treatments

(it’s up to 130+ now – dg)

for various diseases like Alzheimer’s, Type 1 Diabetes, Parkinson’s, and various forms of cancer.

A U.S. doctor, Amid (Amit – dg) Patel, has used adult stem cells to successfully treat over 1,800 patients who suffered from severe heart failure, dramatically increasing their quality of life and chances of survival. Two years ago, I met a man named Stephen Sprague, who had been treated for leukemia through the use of adult stem cells taken from umbilical cord blood. There are success stories like Dr. Patel’s and Stephen Sprague’s scattered across the globe where individuals have been treated for their diseases by adult stem cells, and the hope for future breakthroughs seems limitless. On the other hand, despite millions of dollars of research, not one — not one — embryonic stem-cell trial has resulted in the successful treatment of a human patient.

Perhaps most incredibly, though, is the fact that scientists have just recently figured out how to reprogram adult stem cells

(actually adult skin cells but they are turned into iPS and some argue that they must pass through an adult stem cell state while doing so – dg)

to the point where they function exactly like an embryonic stem cell. These cells, called induced pluripotent stem cells (iPS), can do everything an embryonic stem cell is capable of, only without having to destroy a human embryo. Because of this development, there is likely no medical benefit that can come from embryonic stem-cell research that cannot be obtained from adult stem cells.

(this is way to broad a generalization.  how can we determine what we can learn from something unless it is studied? – dg)

IPS cells also have a greater advantage because they can be derived from a person’s own cells, so a patient’s body is less likely to reject the stem-cell treatment.

(while this is true, many IPS cells are from other peoples cells.  recent iPS cells come from foreskins of other people or allogenic cells as opposed to autologous cells – dg)

Science is truly outpacing the embryonic stem-cell debate. Scientists across the world who were once advocates of this research have reversed course. They overwhelmingly say the future of stem-cell research lies in iPS cells and adult stem cells. Dr. James Thompson, known as the father of embryonic stem-cell research, has said that “it’s probably the beginning of the end for that controversy.” In fact, even the sheep-cloning Prof. Wilmut has abandoned embryonic stem-cell experimentation saying that the use of iPS cells is “extremely exciting and astonishing” and shows more promise for the future.

http://www.humanevents.com/article.php?id=31364/trackback/

Laura Asks #2 – Why would someone like Michael J Fox not seek treatment outside the U.S.?

Posted in ALL ARTICLES, Letters from Laura with tags , , , , , , , on April 7, 2009 by David Granovsky

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  • Why would someone like Michael J Fox not seek treatment outside the U.S.?

Good question Laura. I have heard a number of theories on that…and the answers could apply to Christopher Reeve as well (but not Farrah Fawcett!).  In a nutshell…

Unfrotunately, Michael J Fox is a victim of the misleading media blitz that has been perpetrated on the US public for about 6-8 yrs. All focus was on embryonic stem cell research and no one in the US even knew about the advances that were going on outside except for some scientists and doctors.

If you were to google adult stem cells dated prior to about 3 days before the Superbowl this year, you will barely find even a dozen positive articles in a popular US periodical regarding the benefits of adult stem cells…that were happening any where in the world. And these treatments have been going on for up to 8 or so years! I have even heard rumors of quotes from the few pro-adult stem cell published articles being completely reversed or the articles themselves getting completely pulled without retraction or comment…but that’s a story for another day.

  • That explains the lack of knowledge the general public has about the advances of adult stem cells…but what about the scientists and doctors who are on the cutting edge of research?  Surely they knew what was going on outside the US?

Your logic makes sense and some were aware of what was happening outside the US borders but American scientists and doctors have been trained to believe that the American way (FDA, clinical trials, drug development = $500 million and 7-12 yrs to develop) is the only way to go.

This is also the only way the pharma companies can get patents and sell their drugs exclusively for 5-10 yrs to make back the $500 mill cost of bringing a drug to public.  And make no mistake, the FDA considers stem cells a drug. I have posted a number of article on this subject on my blog.

The scientists and docs have also been trained with an extremely exclusive amero-centric philosophy.  Just about every US scientist will take a verified, completed, peer reviewed clinical trial…even in a well-respected publication like the New England Journal of Medicine, but PERFORMED IN ANOTHER COUNTRY and they will REPEAT IT while following US codes and standards before they will allow themselves to begin to believe the results. I have confirmed this with 3 different scientists.

  • You would think that MJF, with his incredible resources of his assets and foundation, would be able get to the truth behind all of this…

I agree and I’m not quite sure why he is in the dark about adult stem cell and iPSC advances.  I checked his scientific advisory board and he has many brilliant scientists/docs and at least 7 from Europe so I have no idea why he and his foundation have been so incredibly embryonic focused.

Maybe that was his decision?  Maybe when you get to the top echelons of science you are very reluctant to put your name behind any treatment that hasn’t been fully tested, documented, etc.?

I don’t know but I was amazed to watch the video of Dr Oz talking to MJF and Oprah about Parkinsons and what he (Dr Oz) referred to as the death of the stem cell debate.  When I followed the expressions on Oprah and MJF’s faces I was sure that they were hearing about things they had rarely or never heard of before.

These are just a few theories I’ve heard bouncing around.  If anyone has others, I’d love to hear them.

Stem Cell Innovation At Risk In UK, Studies Find

Posted in ALL ARTICLES, BUSINESS OF STEM CELLS with tags , , , , , , , , on April 6, 2009 by David Granovsky

money-stacks

ScienceDaily (Apr. 6, 2009) — Despite great hopes for stem cell therapy, major structural and cultural changes within the National Health Service (NHS) are needed if it is to succeed in the UK. Currently the chances of getting effective treatments into routine use in the short-term are small and the industry is at serious risk of ‘market failure’.

These are the findings of two major studies into the commercialisation and adoption of stem cell therapy carried out by researchers at The University of Nottingham.

Dr Paul Martin, from the Institute of Science and Society said: “While the government has identified regenerative medicine as a national priority and the US has lifted its ban on stem cell therapy, urgent public policy action is needed if it is to become a reality. Although cell therapy is now established as an important branch of medicine, innovative firms struggle to make money, putting the UK industry in a very vulnerable position in the short term. Unless the situation changes the industry will contract and the progress needed to develop important cell therapies will be adversely affected.”

via Stem Cell Innovation At Risk In UK, Studies Find.

Groundbreaking Stem cell therapy Phase II trial on damage heart tissue treatment

Posted in ALL ARTICLES, STEM CELLS IN THE NEWS with tags , , , , , , , , , , on April 4, 2009 by David Granovsky

This is great news also…

but they have been treating MI with adult stem cells successfully in thailand, germany, china for almost 10 yrs now.  Catch UP! -dg

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On March 30, Dr. Roger Gammon, a cardiologist with Austin Heart cardiology group treated the first patient in the world( a 58-year-old Central Texas man) enrolled in a groundbreaking Phase II study. It is one of the nation’s first hospitals to test the new therapy.

The stem cell treatment is administered intravenously and typically takes less than an hour to complete.

The Austin Heart Hospital is one of the 40 hospitals in the nation to conduct this groundbreaking adult stem cell trial, and they are excited enough to lead the way in this important research.

The aim of the study is to test the effectiveness and safety of  administering adult stem cells intravenously to repair damaged heart tissue after a heart attack.

patients are injected with donated adult stem cells from the bone marrow of others. The stems cells are purified by Osiris Therapeutics, Inc., which markets them as a product called Prochymal.

Prochymal is being evaluated for its ability to treat heart damage caused by a heart attack. The active ingredient in the new treatment is adult Mesenchymal Stem Cells (MSCs).  MSCs have the ability to develop into other types of cells and generate new tissue, including heart muscle.

Patients who are interested to participate in the study must receive the treatment within seven days of a heart attack.

Source: FoxBusiness

via Stem Cell Research Blog » Groundbreaking Stem cell therapy Phase II trial on damage heart tissue treatment.

Medical News: ACC: Stem Cell Treatment May Help Repair MI Damage – in Meeting Coverage, ACC from MedPage Today

Posted in ALL ARTICLES, VICTORIES & SUCCESS STORIES with tags , , , , , , , , , , , on April 4, 2009 by David Granovsky

This is great news from my alma mater…but they have been treating MI with adult stem cells successfully in thailand, germany, china for almost 10 yrs now.  Catch UP! -dg

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ACC: Stem Cell Treatment May Help Repair MI Damage

By Todd Neale, Staff Writer, MedPage Today, Published: April 02, 2009

Reviewed by Zalman S. Agus, MD; Emeritus Professor

University of Pennsylvania School of Medicine. Earn CME/CE credit

ORLANDO, April 2 — An infusion of autologous bone marrow progenitor cells may improve outcomes for patients who suffer a severe myocardial infarction, a phase I study suggested.

Action Points:

* Explain to interested patients that the findings come from a phase I study, which is designed to assess safety and feasibility, not efficacy.

* Note that this study was published as an abstract and presented as a poster at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal.

Patients who received the highest doses of enriched CD34+ endothelial progenitor cells in the affected vessel had increased perfusion of the infarct at six months (P=0.01), according to Arshed Quyyumi, M.D., of Emory University in Atlanta.

This is the first study to find a dose response when using enriched progenitor cells to repair damage following an MI severe enough to cause ventricular remodeling, he said at the American College of Cardiology meeting here…

via Medical News: ACC: Stem Cell Treatment May Help Repair MI Damage – in Meeting Coverage, ACC from MedPage Today.