Archive for RESEARCH

PLEASE GO TO MY NEW STEM CELL BLOG BY CLICKING ON “PRESS ME”

Posted in ALL ARTICLES with tags , , , , , , , , , , , on April 7, 2009 by David Granovsky

14 MONTHS,

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..STEM CELL BLOG

STEM CELL BLOG

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Adult Stem Cells Are What Work

Posted in ALL ARTICLES, STEM CELLS IN THE NEWS with tags , , , , , , , , , on April 7, 2009 by David Granovsky

I think this Rep has been reading my blog and drinking the kool-aid! Only a few corrections to what he wrote. -dg

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Adult Stem Cells Are What Work

by Rep. J. Randy Forbes, 04/07/2009

Prof. Ian Wilmut of Edinburgh University is hardly a household name. However, most people would recognize his Nobel-Prize-winning scientific development. Prof. Wilmut was the individual who led the team that created the cloned sheep Dolly and pioneered a technique many would want to use for a type of embryonic stem-cell research. His action resulted in both uproar and applause all over the world and was instrumental in bringing the discussion of cloning and stem-cell research from the laboratory to the dinner table.

For years, the moral and ethical issue of destroying human embryos for scientific experimentation has been the biggest argument against embryonic stem-cell research.

(besides causing tumors and severe rejection issues -dg)

But now there is a new argument against embryonic stem-cell research: science.

Just recently, President Obama signed an executive order lifting the ban on the use of federal funds for embryonic stem-cell research, an act based more on politics than it was on science. (Private funding for this research has never been banned.) His action reignited the contentious issue for many individuals in the U.S. — it also ignored the miracles we’ve seen in advancing science.

Adult stem-cells are derived from umbilical cords, wisdom teeth, amniotic fluid, and various tissues, and they don’t hold the same ethical concerns that stem-cells taken from human embryos do. Over the years, adult stem cells have resulted in 73 successful treatments

(it’s up to 130+ now – dg)

for various diseases like Alzheimer’s, Type 1 Diabetes, Parkinson’s, and various forms of cancer.

A U.S. doctor, Amid (Amit – dg) Patel, has used adult stem cells to successfully treat over 1,800 patients who suffered from severe heart failure, dramatically increasing their quality of life and chances of survival. Two years ago, I met a man named Stephen Sprague, who had been treated for leukemia through the use of adult stem cells taken from umbilical cord blood. There are success stories like Dr. Patel’s and Stephen Sprague’s scattered across the globe where individuals have been treated for their diseases by adult stem cells, and the hope for future breakthroughs seems limitless. On the other hand, despite millions of dollars of research, not one — not one — embryonic stem-cell trial has resulted in the successful treatment of a human patient.

Perhaps most incredibly, though, is the fact that scientists have just recently figured out how to reprogram adult stem cells

(actually adult skin cells but they are turned into iPS and some argue that they must pass through an adult stem cell state while doing so – dg)

to the point where they function exactly like an embryonic stem cell. These cells, called induced pluripotent stem cells (iPS), can do everything an embryonic stem cell is capable of, only without having to destroy a human embryo. Because of this development, there is likely no medical benefit that can come from embryonic stem-cell research that cannot be obtained from adult stem cells.

(this is way to broad a generalization.  how can we determine what we can learn from something unless it is studied? – dg)

IPS cells also have a greater advantage because they can be derived from a person’s own cells, so a patient’s body is less likely to reject the stem-cell treatment.

(while this is true, many IPS cells are from other peoples cells.  recent iPS cells come from foreskins of other people or allogenic cells as opposed to autologous cells – dg)

Science is truly outpacing the embryonic stem-cell debate. Scientists across the world who were once advocates of this research have reversed course. They overwhelmingly say the future of stem-cell research lies in iPS cells and adult stem cells. Dr. James Thompson, known as the father of embryonic stem-cell research, has said that “it’s probably the beginning of the end for that controversy.” In fact, even the sheep-cloning Prof. Wilmut has abandoned embryonic stem-cell experimentation saying that the use of iPS cells is “extremely exciting and astonishing” and shows more promise for the future.

http://www.humanevents.com/article.php?id=31364/trackback/

Laura Asks #2 – Why would someone like Michael J Fox not seek treatment outside the U.S.?

Posted in ALL ARTICLES, Letters from Laura with tags , , , , , , , on April 7, 2009 by David Granovsky

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  • Why would someone like Michael J Fox not seek treatment outside the U.S.?

Good question Laura. I have heard a number of theories on that…and the answers could apply to Christopher Reeve as well (but not Farrah Fawcett!).  In a nutshell…

Unfrotunately, Michael J Fox is a victim of the misleading media blitz that has been perpetrated on the US public for about 6-8 yrs. All focus was on embryonic stem cell research and no one in the US even knew about the advances that were going on outside except for some scientists and doctors.

If you were to google adult stem cells dated prior to about 3 days before the Superbowl this year, you will barely find even a dozen positive articles in a popular US periodical regarding the benefits of adult stem cells…that were happening any where in the world. And these treatments have been going on for up to 8 or so years! I have even heard rumors of quotes from the few pro-adult stem cell published articles being completely reversed or the articles themselves getting completely pulled without retraction or comment…but that’s a story for another day.

  • That explains the lack of knowledge the general public has about the advances of adult stem cells…but what about the scientists and doctors who are on the cutting edge of research?  Surely they knew what was going on outside the US?

Your logic makes sense and some were aware of what was happening outside the US borders but American scientists and doctors have been trained to believe that the American way (FDA, clinical trials, drug development = $500 million and 7-12 yrs to develop) is the only way to go.

This is also the only way the pharma companies can get patents and sell their drugs exclusively for 5-10 yrs to make back the $500 mill cost of bringing a drug to public.  And make no mistake, the FDA considers stem cells a drug. I have posted a number of article on this subject on my blog.

The scientists and docs have also been trained with an extremely exclusive amero-centric philosophy.  Just about every US scientist will take a verified, completed, peer reviewed clinical trial…even in a well-respected publication like the New England Journal of Medicine, but PERFORMED IN ANOTHER COUNTRY and they will REPEAT IT while following US codes and standards before they will allow themselves to begin to believe the results. I have confirmed this with 3 different scientists.

  • You would think that MJF, with his incredible resources of his assets and foundation, would be able get to the truth behind all of this…

I agree and I’m not quite sure why he is in the dark about adult stem cell and iPSC advances.  I checked his scientific advisory board and he has many brilliant scientists/docs and at least 7 from Europe so I have no idea why he and his foundation have been so incredibly embryonic focused.

Maybe that was his decision?  Maybe when you get to the top echelons of science you are very reluctant to put your name behind any treatment that hasn’t been fully tested, documented, etc.?

I don’t know but I was amazed to watch the video of Dr Oz talking to MJF and Oprah about Parkinsons and what he (Dr Oz) referred to as the death of the stem cell debate.  When I followed the expressions on Oprah and MJF’s faces I was sure that they were hearing about things they had rarely or never heard of before.

These are just a few theories I’ve heard bouncing around.  If anyone has others, I’d love to hear them.

Law of Magnetism DOES NOT WORK in the US

Posted in ALL ARTICLES, STEM CELLS IN THE NEWS with tags , , , , , , , , on April 6, 2009 by David Granovsky
  1. Adult stem cells are relatively smart and will go to their “designated organ” and repair what needs repairing (some “spilling” occurs).
  2. Nano technology will make them Einstein-ian.
  3. And magnets will control where they go like the slot cars I used to have as a kid.

So, the bottom line is…

you can get stem cells to go ANYWHERE YOU NEED THEM in the human body…

except for

INTO A PATIENT THAT NEEDS THEM IN THE US!

Sorry Farrah. Tough luck. -dg

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Bone-repairing stem cell jab hope

Page last updated at 12:39 GMT, Monday, 6 April 2009 13:39 UK

By Michelle Roberts

It may be possible to control stem cells with a magnet

Doctors may soon be able to patch up damaged bones and joints anywhere in the body with a simple shot in the arm.

A team at Keele University is testing injectible stem cells that they say they can control with a magnet.

Once injected these immature cells can be guided to precisely where their help is needed and encouraged to grow new cartilage and bone, work on mice shows.

The aim is to treat patients with injuries and arthritis the UK National Stem Cell Network conference heard.

The ultimate aim is to repair cartilage and bone

Professor Alicia El Haj

Keele University

Professor Alicia El Haj, working with Professor John Dobson, also of Keele University, says the technology, patented by Magnecell, could be tested in humans within five years.

It would provide a way to treat disease without invasive surgery or powerful drugs.

The injection would use the patient’s own stem cells, harvested from their bone marrow.

These mesenchymal cells would be treated in the lab to give them a coating of minute magnetic particles.

Use in scans

These same magnetic nanoparticles are already approved in the US where they are routinely used as an agent to make MRI scans clearer to read.

Targeted magnetic fields could then move the cells around the body to the desired place and switch them into action without the need for drugs or other biochemical triggers.

Professor Al Haj said: “The ultimate aim is to repair cartilage and bone. We have been able to grow new bone in mice. Now we will look at whether we can repair damaged sites in goats.

“We should be able to move to human trials within five years.”

Meanwhile, experts at the University of Southampton, led by Professor Richard Oreffo, have treated four patients with hip joint problems using stem cell therapy.

The technique combines the patients own bone marrow stem cells with donor bone cells to patch-repair damaged bones that would otherwise need treatment with metal plates and pins.

They say it is only a matter of years before their method could be used routinely to treat some of the 60,000 people who fracture a hip in the UK each year.

via BBC NEWS | Health | Bone-repairing stem cell jab hope.

Embryonic, adult, iPSC & epSPC Research

Posted in ALL ARTICLES with tags , , , , , , , , , , on April 3, 2009 by David Granovsky

time_clock

A moment in time…

Embryonic stem cell research has taught us an incredible amount and we have much more to learn from them. Unfortunately, embryonics have overshadowed the advances of adult stem cell treatments.

There is a grim fairy tale going on in the US today derived from the love/hate relationship with embryonic stem cell TREATMENT research. You can view the 6 part series here: http://repairstemcell.wordpress.com/2009/03/30/a-grim-fairy-tale-americas-doomed-love-affair-with-embryonic-stem-cell-research-intro-the-romance-is-an-illusion/

The US is waking up to the fact that embryonic stem cells will produce no cures for 7-12 years if then and adult stem cells have been treating people around the world for up to 10 years successfully.
http://repairstemcell.wordpress.com/2009/04/03/oz-oprah-michael-j-fox-and-embryonic-stem-cell-research/

Both will continue, in addition to iPSC and epSPC research, and will do so accompanied by the hysteria, controversy, misinformation and confusion that they have been surrounded by for the past 10 years. My only hope is that the uneven focus on embryonic research does not continue to overshadow the successes of adult stem cells, thereby depriving more millions of Americans from receiving treatments that are available to them just a plane trip away.

Adult Spinal Stem Cells Reverse Paralysis in Rats

Posted in ALL ARTICLES, VICTORIES & SUCCESS STORIES with tags , , , , , , , , on April 2, 2009 by David Granovsky

rat-robotBoth the stem cell vocabulary and the scientific advancements seem to be growing at an almost logarithmic pace!

Stem Cell Acronym for the day:  epSPCs = ependymal stem/progenitor cells

Ependyma is the thin epithelial membrane lining the ventricular system of the brain and the spinal cord. Ependyma is one of the four types of neuroglia in the central nervous system. It is involved in the production of cerebrospinal fluid (CSF). wiki -dg

Injured spinal stem cells effectively differentiate into nerve cells

Publish date: Apr 1, 2009

WEDNESDAY, April 1 (HealthDay News) — Spinal stem cells taken from adult rats with an injured spinal cord are effective at differentiating into oligodendrocytes and motor neurons and can reverse paralysis when transplanted into rats with a spinal cord injury, according to a study published in the March issue of Stem Cells.

Victoria Moreno-Manzano, and colleagues from the Centro de Investigacion Principe Felipe in Valencia, Spain, studied the characteristics of ependymal stem/progenitor cells (epSPCs) from adult rats with a spinal cord injury and from uninjured adult rats. Ependymal cells line the central canal of the spinal cord and can regenerate the injured spinal cord in lower vertebrates; mammalian turnover of epSPCs declines during the postnatal period but can proliferate in response to injury, the study authors note.

The investigators found that epSPCs taken from injured rats proliferated 10 times faster in vitro than epSPCs from uninjured rats. Neurospheres derived from epSPCs from injured rats were more effective in differentiating into oligodendrocytes and functional spinal motor neurons. Transplantation of epSPCs from injured rats into a rat model of severe spinal cord contusion led to significant recovery of motor activity one week after injury, the researchers report. The transplanted cells migrated from the rostral and caudal regions of the transplant to axons in and around the lesion.

“Our findings demonstrate that modulation of endogenous epSPCs represents a viable cell-based strategy for restoring neuronal dysfunction in patients with spinal cord damage,” Moreno-Manzano and colleagues conclude.

via http://www.modernmedicine.com/modernmedicine/Modern+Medicine+Now/Adult-Spinal-Stem-Cells-Reverse-Paralysis-in-Rats/ArticleNewsFeed/Article/detail/591031?contextCategoryId=40148

Abstract
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Stem Cell Research Now Helping Stroke Patients | Adult Stem Cell Research

Posted in ALL ARTICLES with tags , , , , , , , , on April 1, 2009 by David Granovsky
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Stem Cell Research Now Helping Stroke Patients

Posted 1 April, 2009 in Stroke |Stem Cell Research Paying Dividends to Stroke Patient

Thanks to advances in stem cell research, stroke patients can now be helped with their own Adult Stem Cells. Doctors at University of Texas Medical School in Houston treated a stroke patient for the very first time in the United States using the patient’s own stem cells.

Patient’s Own Adult Stem Cells Used for Stroke

Roland Henrich was the first American (in the United States) to be treated with his own Adult stem cells. From the stem cell article:

A University of Texas Medical School at Houston team last week injected stem cells taken from bone marrow of the trial’s first patient (Roland), who arrived at Memorial Hermann Hospital’s emergency department too late to receive tissue plasminogen activator, the clot-busting drug proven to treat stroke if given promptly.

Doctors say Roland is doing well although it is too early to tell if it is because of the stem cell treatment.

Adult Stem Cells for Stroke- Available to the Masses in 2019

Note this date April 1, 2009– if this treatment using his own stem cells is effective (and it should be) , it will take approximately 10 years before this stem cell treatment becomes available to the general population of the United States because of the FDA’s stance that says your own Adult Stem Cells are drugs.

Because- Unfortunately, this is only a part of a  Phase I trial to demonstrate safety-  Savitz said it should take about a year to enroll its 10 patients, who must arrive at Memorial Hermann more than three hours after suffering a stroke but within three days.

This goes to my point about the FDA classifying your own Adult Stem Cells as drugs–

About 1 year to enroll all the patients, another year to follow up on the results, then probably another year before the FDA says “OK, you can do a Phase II trial which will take even longer than the first one— and if that works out, ok, you can do a Phase III trial.  And then, when that is finally completed, the FDA  may then take their time before approving it as a treatment.   10 years from NOW.  Although the treatment is safe and no side effects because it is your own stem cells.

As I said before here in this post about US Doctors Challenging the FDA , just because it is in the trial phase does not mean it will be able to be used in the United States anytime soon.

Now, I am familiar with stem cell clinics all around the world that are having success using Adult Stem Cells to help stroke patients now.  But because of these ridiculous FDA rules-  Americans will have to wait 10 years for this treatment for stroke.  Think how many stroke victims will needlessly suffer during that time.

Other Stem Cell Therapy for Stroke Stories

This follows that “Stem Cell Tea Bag” that was used to treat (and help) a German stroke victim.

via Stem Cell Research Now Helping Stroke Patients | Adult Stem Cell Research.