Archive for spinal

WMU News – Alumna discusses embryonic stem cell research

Posted in ALL ARTICLES, STEM CELLS IN THE NEWS with tags , , , , , , , , on April 3, 2009 by David Granovsky

I look forward to hearing how she handled the embryonic rejection issues and the tendency to form tumors. -dg


WMU News

Alumna discusses embryonic stem cell research

April 2, 2009

KALAMAZOO–Western Michigan University graduate Jacqueline Kueh, a doctoral student in England, returns to WMU to discuss her research in spinal cord repair and in embryonic stem cells at noon Wednesday, April 8, in Kirsch Auditorium of the Fetzer Center.

A doctoral candidate at the University College London Institute of Neurology, Kueh will address two separate lines of her research in “Pluripotency of Embryonic Stem Cells and New Developments in Spinal Cord Repair.”

After graduating from WMU in 2003, Kueh returned to her native Southeast Asia and did research at both the National University of Singapore, under the direction of Dr. Ariff Bongso, a pioneer in human embryonic stem cell research, and at the Genome Institute of Singapore. In 2006, she began her doctoral studies at University College London, where she works under Dr. Geoffrey Raisman, a pioneer in spinal cord repair.

Originally from Malaysia, Kueh began her undergraduate studies at Sunway College. She graduated summa cum laude from WMU with a bachelor’s degree in biomedical sciences. While at WMU, she was a Phi Kappa Phi Scholar and was one of the original Monroe-Brown Research Scholars in 2002. She also was active in the Malaysian Student Organization and worked in 2003 as a freshman orientation leader.

For more information about Kueh’s presentation, contact Dr. David Huffman at or (269) 387-2865.

Media contact: Thom Myers, (269) 387-8400,

WMU News
Office of University Relations
Western Michigan University
Kalamazoo MI 49008-5433 USA
(269) 387-8400

via WMU News – Alumna discusses embryonic stem cell research.


Adult Spinal Stem Cells Reverse Paralysis in Rats

Posted in ALL ARTICLES, VICTORIES & SUCCESS STORIES with tags , , , , , , , , on April 2, 2009 by David Granovsky

rat-robotBoth the stem cell vocabulary and the scientific advancements seem to be growing at an almost logarithmic pace!

Stem Cell Acronym for the day:  epSPCs = ependymal stem/progenitor cells

Ependyma is the thin epithelial membrane lining the ventricular system of the brain and the spinal cord. Ependyma is one of the four types of neuroglia in the central nervous system. It is involved in the production of cerebrospinal fluid (CSF). wiki -dg

Injured spinal stem cells effectively differentiate into nerve cells

Publish date: Apr 1, 2009

WEDNESDAY, April 1 (HealthDay News) — Spinal stem cells taken from adult rats with an injured spinal cord are effective at differentiating into oligodendrocytes and motor neurons and can reverse paralysis when transplanted into rats with a spinal cord injury, according to a study published in the March issue of Stem Cells.

Victoria Moreno-Manzano, and colleagues from the Centro de Investigacion Principe Felipe in Valencia, Spain, studied the characteristics of ependymal stem/progenitor cells (epSPCs) from adult rats with a spinal cord injury and from uninjured adult rats. Ependymal cells line the central canal of the spinal cord and can regenerate the injured spinal cord in lower vertebrates; mammalian turnover of epSPCs declines during the postnatal period but can proliferate in response to injury, the study authors note.

The investigators found that epSPCs taken from injured rats proliferated 10 times faster in vitro than epSPCs from uninjured rats. Neurospheres derived from epSPCs from injured rats were more effective in differentiating into oligodendrocytes and functional spinal motor neurons. Transplantation of epSPCs from injured rats into a rat model of severe spinal cord contusion led to significant recovery of motor activity one week after injury, the researchers report. The transplanted cells migrated from the rostral and caudal regions of the transplant to axons in and around the lesion.

“Our findings demonstrate that modulation of endogenous epSPCs represents a viable cell-based strategy for restoring neuronal dysfunction in patients with spinal cord damage,” Moreno-Manzano and colleagues conclude.


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World’s Leading Scientists Meet to Examine Barriers for Stem Cell Therapies to Cure Spinal Cord Injury

Posted in ALL ARTICLES, STEM CELLS IN THE NEWS with tags , , , , , , , , on April 1, 2009 by David Granovsky


World’s Leading Scientists Meet to Examine Barriers for Stem Cell Therapies to Cure Spinal Cord Injury

Following President Barack Obama’s decision to lift the ban on federal funding for embryonic stem cell research, medical and scientific experts will converge at the University of Georgia to discuss how recent advances in stem cell research can be translated into cures for spinal cord injuries.

The second Spinal Cord Workshop, a program of the Bedford Stem Cell Research Foundation, will be held on Saturday, April 4 from 8:30 a.m. to 5:30 p.m. at the Paul D. Coverdell Center for Biomedical and Health Sciences.

Every year close to 11,000 people sustain spinal cord injuries in the United States, while more than 200,000 Americans live each day with a disability caused by them.

“Because spinal cord injury usually occurs in otherwise healthy, young adults, it is an especially attractive candidate for a cure for stem cell therapy,” said Ann Kiessling, director of the Bedford Stem Cell Research Foundation. “The big question is whether a ‘moon shot’ approach will produce a cure, or if there is still too much basic science yet unknown.”

The workshop is hosted by UGA’s Regenerative Bioscience Center. Additional support is provided by the UGA Biomedical and Health Sciences Institute, the Shepherd Center in Atlanta, and Millipore, Inc.

“The University of Georgia is fortunate to team up with the Bedford Foundation to host these leading experts in spinal cord therapies to discuss and develop new paths forward for spinal cord injuries,” said Steven Stice, director of the Regenerative Bioscience Center. “In addition, Georgia’s recent legislation aimed at restricting stem cell research makes this workshop an especially timely one.”

Created in 1996, the Bedford Stem Cell Research Foundation is a Massachusetts-based public charity and biomedical institute that exists to conduct stem cell and related research for diseases and conditions that currently have no cure.

The Regenerative Bioscience Center brings UGA’s expertise, resources and accomplishments in human embryonic stem cell research under one umbrella, while contributing to the University’s educational and outreach missions with student research experiences and public lectures, symposia, and workshops communicating the benefits and risks of regenerative bioscience.

The event serves as a follow-up to the inaugural Spinal Cord Workshop held at UGA in March 2008, titled “Spinal Cord Injury: What Are The Barriers To Cure?”

Workshop faculty this year include:
Hans Keirstead, Ph.D, associate professor of anatomy and neurobiology, University of California at Irvine, Reeve-Irvine Research Center; Douglas Kerr, M.D., Ph.D., associate professor of neurology, molecular biology and immunology, and director, John Hopkins Transverse Myelitis Center; John W. McDonald, M.D., Ph.D., director, International Center for Spinal Cord Injury, Kennedy Krieger Institute; Steven L. Stice, Ph.D., professor, GRA Eminent Scholar, director of the Regenerative Bioscience Center at the University of Georgia and CSO, Aruna Biomedical Inc; Keith Tansey, M.D., Ph.D., director, Spinal Cord Injury Research, Shepherd Center; Scott Wittemore, Ph.D., professor and vice chairman for research, Department of Neurological Surgery, University of Louisville; Wise Young, M.D., Ph.D., professor and chair, Department of Cell Biology and Neuroscience, Rutgers University, and director, W.M. Keck Center for Collaborative Neuroscience.

Registration information for the 2009 workshop, as well as video from the 2008 workshop talks, is available online at:

via – World’s Leading Scientists Meet to Examine Barriers for Stem Cell Therapies to Cure Spinal Cord Inju.

Il :: RAISMAN/ The best results are coming from the adult stem cell research programmes

Posted in ALL ARTICLES, STEM CELLS IN THE NEWS with tags , , , , , , , , , on March 30, 2009 by David Granovsky

spine-sci-treat-heal-cord-spinalRAISMAN/ The best results are coming from the adult stem cell research programmes

Geoffrey Raisman, lunedì 30 marzo 2009

In many countries – and certainly on media – the research on stem cells seems to be concentrated on embryonic stem cells considered as the way to provide treatments for many genetic disease that are at present not curable. This approach risks to overshadow the research on adult stem cells that many evidences show to be probably more effective and at hand. Professor Geoffrey Raisman is the director of the Spinal Repair Unit at the University College London Institute of Neurology. He leads a research team whose work could ultimately lead to the repair of spinal cord injuries in humans and he is working with adult stem cells. has asked professor Raisman to take stock of the situation.

Professor Raisman, stem cells and particularly embryonic stem cells are at the centre of media attention. But, from a scientific point of view, what is the real state of the art in the research on stem cells?

Embryonic stem cells have the property to divide indefinitely and turn into any tissue in the body. From the point of view of transplanting embryonic stem cells these are not entirely an advantage. Uncontrolled division would lead to an invasive tissue not properly integrated into the body. What is required for repair are cells already differentiated into the tissue type requiring repair. Embryonic stem cells used as donor issue would be foreign to the host and therefore under immune attack.

You recently said that adult stem cells are much more promising therapeutically. Could you broaden this statement?

Transplants of adult stem cells are matched in state of maturity to the recipient, they are already committed to making the tissue required, and they are not immunologically incompatible.

via Il :: RAISMAN/ The best results are coming from the adult stem cell research programmes.

Stepping Towards A Paralysis Cure, A Tale Of Two Supermen Stem Cells Cure 23 Year Old Male of Paralysis – C6-C7 injury

Posted in ALL ARTICLES, BEST OF THE BEST, VICTORIES & SUCCESS STORIES with tags , , , , , , , , , , , on March 28, 2009 by David Granovsky




By David Granovsky

“It was the best of times, it was the worst of times…”

A Tale of Two Cities

Superman #1 – Christopher Reeve:

1995 – Thrown from his horse, lands on his head, destroying the first and second cervical vertebrae, and is paralyzed.

The cause: “Spinal Cord Injury” (SCI)

2002 – RSC treatments begin improving the lives of severe SCI patients in Portugal.

2004 – Two of these improved SCI patients testify before Congress regarding the benefits of RSC for treating SCI.  After 2 years of RSC treatments providing SCI improvements, Mr. Reeve disregarded this information, choosing instead to “believe in” the promise of embryonic stem cells.

Oct. 10, 2004 – At Northern Westchester Hospital suffers cardiac arrest brought on by infection.

CONCLUSION: After battling paralysis for 9 years Superman #1 dies.

March 26, 2009 – 4 ½ years after Mr. Reeves’ death, not one SCI patient has been treated with embryonic stem cells.

Superman #2 – Male, 23 years old:

Prior motor vehicle accident victim with cervical bilateral inter facet dislocation, C6-C7 injury.

Feb 28, 2008 – Implanted with fresh autologous (from his own body) bone marrow stem cells in Argentina.

March 15, 2008 – Implanted with cultured and expanded mesenchymal stem cells. Clinical indications after implantation were intense physical therapy and MRI each 6 months.

CONCLUSION: After receiving two Repair Stem Cell treatments, intensive physical therapy and with the assistance of a walker, Superman #2 is now walking on his own power, has sensation in his legs, has hair growing on his legs, and has bladder control.

Repair stem cells are the only medicine known to man capable of achieving significant results with the most seriously injured SCI patients.  He is living and walking proof that when Western Medicine dogma declares: “severe SCI patients are permanently paralyzed”, it is true only when Repair Stem Cells are prohibited, as they have been, and will be for years to come, in America.


There are roughly 100 stem cell treatment centers in the world. The Repair Stem Cell Institute (RSCI) recommends 8 of them as the world’s top Treatment Centers. It is no coincidence that among the 8 are the three world leaders in the treatment of SCI. These three treatment centers have destroyed the two myths of Western SCI treatment:

(1) Severe SCI victims will always be paralyzed.


(2) Embryonic stem cells have more treatment promise than RSC.

The first successful treatment of SCI patients by the three world leaders:

  • Dr. Carlos Lima in Portugal in 2002
  • Beike’s team in China in 2005-6
  • Dr. Roberto Fernandez-Vina in Argentina in 2008

–    Three leading stem cell treatment centers,

–    all recommended by RSCI

–    on three continents,

–    using three different types of RSC and

–    using three different procedures to implant the stem cells

–    over a 6 year period,

Typical SCI Progress Scale after a single RSC treatment:

Average success – ability to flex abdominal muscles

Good success – ability to feel the bladder

Super success – ability to control the bladder

After that, there may be a second stem cell implant some months later, but, in order to progress toward walking, the one mandatory therapy is Physical

Rehabilitation – years of exceptionally difficult Physical Rehabilitation.

Click here to see what is involved in Rehab:

See a video showing what Repair Stem Cells did for SUPERMAN 2. This is POWERFUL! (Click this link and scroll to video; wait about 4 seconds):

Click here to see videos of Pioneer Doctor Carlos Lima, Steve “Mr. Rehab” Hinderer (Click this and scroll to video):

“You go on. You set one foot in front of the other, and if a thin voice cries out, somewhere behind you, you pretend not to hear, and keep going.”

– Geraldine Brooks (Pulitzer Prize winning author of “March”)

Published 03/27/09 in Repair Stem Cell Institute Newsletter #3 –

For treatment information:

To view archived newsletters or join the newsletter mailing list:

Adult Stem Cell Study Demonstrates Improved Quality of Life for Patients Suffering from Spinal Cord Injury

Posted in ALL ARTICLES, VICTORIES & SUCCESS STORIES with tags , , , , , , , , , , , , , , on March 26, 2009 by David Granovsky


Adult Stem Cell Study Demonstrates Improved Quality of Life for Patients Suffering from Spinal Cord Injury

March 16, 2009 11:00 AM Eastern Daylight Time –

Patients Suffering from Acute and Chronic Spinal Cord Injury Regain Sensation, Motor Functions and Bladder Control According to a Safety and Feasibility Study Published Today in Cell Transplantation

LOS ANGELES–(BUSINESS WIRE)–DaVinci Biosciences announced today the publication of study results demonstrating the safety and feasibility of its acute and chronic spinal cord injury therapy platform in issue 17(12) of Cell Transplantation, a peer-reviewed journal focused on regenerative medicine. The study demonstrates that administering adult autologous bone marrow derived stem cells via multiple routes is feasible, safe, and most importantly, improves the quality of life for both acute and chronic spinal cord injury (SCI) patients.

The study documents the first eight of 52 patients (four acute and four chronic) who were administered autologous bone marrow derived stem cells using a multiple route delivery technique. A two-year follow-up was performed on these first eight patients. Using sequential MRIs, the follow-up demonstrated noticeable morphological changes within the spinal cord after administration of autologous stem cells. Participating spinal cord injury patients experienced varying degrees of improvement in their quality of life, such as increased bladder control, regained mobility and sensation. Most importantly, the study demonstrated no adverse effects such as tumor formation, increased pain, and/or deterioration of function following administration of autologous stem cells. In a video provided by the Luis Vernaza Hospital, patients involved in the study can be seen discussing their improved quality of life at: For more information on the study or to read the published article, visit

“While this was only a safety and feasibility study, the outcome for our patients was amazing and we plan to build upon our results,” said Francisco Silva, President of DaVinci Biosciences.

About DaVinci Biosciences

DaVinci Biosciences LLC is a privately held company dedicated to advancing therapies that improve the quality of life for individuals suffering from trauma, disease and degenerative disorders. Through independent research and partnerships with universities, medical research institutions, and hospitals, DaVinci Biosciences continues to discover biological breakthroughs relating to and further improving the treatment of degenerative disorders and injury. DaVinci Biosciences is headquartered in Costa Mesa, California. For more information please visit

via BioSpace – Corporate News on the Net brought to you by Business Wire.

More Spinal Cord Injury Success from adult stem cells

Posted in ALL ARTICLES, VICTORIES & SUCCESS STORIES with tags , , , , , , , , , on March 25, 2009 by David Granovsky